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PART 5: Human
Studies
Compared with Animal Studies,
Human studies with CLA are far fewer and less impressive.
Here they are:
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- 3.9g/day of CLA for 63 days did not show
benefits regarding the prevention of atherosclerosis; blood
cholesterol and lipoprotein levels did not change;42
- 3.9g/day of CLA for 63 days did not show
benefits regarding blood coagulation and platelet function;43
- Increasing CLA in the fetus correlated with
decreased length of gestation;44
- 3.9g/day of CLA for 63 days did not show
benefits regarding immune function in human females;45
- 4.2g/day of CLA increased lipid peroxidation
in men with abdominal obesity after one month of use;46
- In patients with chronic renal failure,
CLA did not help;47
- At 3 g/day, CLA resulted in no fat loss,
no change in appetite, no change in blood glucose, but
increased insulin and produced a transient decrease in
leptin; CLA did not affect these parameters in a manner
that promotes fat loss;48
- At 3 g/day, CLA provided no change in body
composition, energy expenditure, fat oxidation, or respiratory
exchange ratio;49
- 4.2 g/day of CLA increased lipid peroxidation,
apparently by both enzymatic and non-enzymatic processes;50 3.4 g/day of CLA reduced body fat mass;
more than 3.4 g/day did not provide any additional benefit;51
- 16 g/day of omega-6 LA from safflower oil
did not result in any increase in CLA in the body, i.e.
the human body does not make CLA from LA;52
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